The AI-powered drug discovery and precision medicine market is rapidly growing as pharmaceutical companies, biotech firms, and healthcare providers leverage artificial intelligence to accelerate drug development and enhance personalized treatment strategies.
AI-driven algorithms analyze vast datasets, including genomics, clinical trials, and molecular interactions, to identify promising drug candidates, predict patient responses, and optimize clinical workflows. This market is fueled by advancements in machine learning, big data analytics, and computational biology, reducing drug development timelines and costs while improving treatment efficacy. As regulatory bodies and industry leaders embrace AI’s potential, investment and partnerships in this space are surging, positioning it as a transformative force in modern medicine.
The US has seen $172bn raised in 730 funding rounds to 292 companies. The median number o funding rounds per company is three. The compound annual growth rate (CAGR) for this space is at 5.3% with a median maturity of 8 years.
Below we've compiled a curated list of 15 AI-powered drug discovery and precision medicine companies from the United States. Download the full market report to discover insights and companies in each subspace.
PathomIQ
PathomIQ is an artificial intelligence company that develops biomarker discovery and precision medicine tools for cancer diagnosis.
Headquarter: Cupertino, United States
Founded: 2018
Headcount: 9
Funding: Unknown
Company website: https://pathomiq.com
LinkedIn: https://linkedin.com/company/pathomiq
ENSEM Therapeutics
ENSEM Therapeutics is a biotechnology company focusing on high value and difficult-to-drug oncology targets
Headquarter: Medford, United States
Founded: 2021
Headcount: 34
Funding: Series A ($10m), Oct 2023. 2 rounds ($77m total)
Company website: https://ensemtx.com
LinkedIn: https://linkedin.com/company/ensemtx
Polaris Quantum Biotech
Polaris Quantum Biotech revolutionizes drug design by joining quantum computing with AI and precision medicine.
Headquarter: Durham, United States
Founded: 2020
Headcount: 11
Funding: Seed ($2.1m), Aug 2021. 1 round ($2.1m total)
Company website: https://polarisqb.com
LinkedIn: https://linkedin.com/company/polarisqb
Owkin
Owkin is an AI precision medicine company with a vision to find the right drug for every patient.
Headquarter: New York, United States
Founded: 2016
Headcount: 230
Funding: Series B ($50m), Jun 2022. 8 rounds ($304.1m total)
Company website: https://owkin.com
LinkedIn: https://linkedin.com/company/owkin
Nucleai
Nucleai is a spatial biology company that has developed an AI-powered platform to enhance drug development and improve patient outcomes.
Headquarter: Chicago, United States
Founded: 2017
Headcount: 82
Funding: Venture ($14m), Apr 2024
Company website: https://nucleai.ai
LinkedIn: http://www.linkedin.com/company/nucleai-ai
PathAI
PathAI develops technology that assists pathologists in making accurate diagnoses for every patient, every time.
Headquarter: Boston, United States
Founded: 2016
Headcount: 330
Funding: M&A, May 2024. 7 rounds ($355.2m total)
Company website: https://pathai.com
LinkedIn: https://linkedin.com/company/pathai
BullFrog AI
BullFrog AI is a developer of an artificial intelligence platform intended to help companies in clinical development.
Headquarter: Boyds, United States
Founded: 2016
Headcount: 10
Funding: IPO, Feb 2023. 5 rounds ($9.9m total)
Company website: https://bullfrogai.com
LinkedIn: https://linkedin.com/company/bullfrogai
Archetype Therapeutics
Archetype Therapeutics is an AI-native biotech firm specializing in computational drug discovery and repurposing.
Headquarter: Winchester, United States
Founded: 2022
Headcount: 10
Funding: Unknown
Company website: https://archetypetx.com
LinkedIn: https://linkedin.com/company/archetypetx
Treeline Biosciences
Treeline Biosciences is a biotech company building transformative precision medicines for patients with cancer and other serious conditions.
Headquarter: Watertown, United States
Founded: 2021
Headcount: 160
Funding: Undisclosed ($421m), Oct 2024. 3 rounds ($894.27m total)
Company website: https://treeline.bio
LinkedIn: http://www.linkedin.com/company/treeline-biosciences
Vesalius Therapeutics
Vesalius Therapeutics is focused on redefining the understanding and treatment of the diseases that drive ninety percent of human illness.
Headquarter: Cambridge, United States
Founded: 2019
Headcount: 50
Funding: Series A ($75m), Mar 2022. 1 round ($75m total)
Company website: https://vesaliustx.com
LinkedIn: https://linkedin.com/company/vesaliustx
HopeAI
AI-powered clinical evidence for drug development and precision medicine
Headquarter: Princeton, United States
Founded: 2023
Headcount: 10
Funding: Pre-Seed ($1.1m), Jan 2024. 1 round ($1.1m total)
Company website: https://hopeai.co
LinkedIn: https://linkedin.com/company/hopeai-co
BioSymetrics
BioSymetrics transforms the science of massive data analytics and prediction through its groundbreaking pre-processing.
Headquarter: New York, United States
Founded: 2015
Headcount: 26
Funding: M&A, Feb 2025
Company website: https://www.biosymetrics.com
LinkedIn: https://linkedin.com/company/biosymetrics
Zephyr AI
Zephyr AI is a healthcare technology company that reshapes traditional approaches to drug discovery and precision medicine.
Headquarter: Fairfax Station, United States
Founded: 2020
Headcount: 46
Funding: Series A ($111m), Mar 2024. 2 rounds ($129.5m total)
Company website: https://zephyrai.bio
LinkedIn: https://linkedin.com/company/zephyr-ai
Atomwise
Atomwise develops artificial intelligence systems using powerful deep learning algorithms and supercomputers for drug discovery.
Headquarter: San Francisco, United States
Founded: 2012
Headcount: 59
Funding: Series C ($45m), Jan 2024. 10 rounds ($221.65m total)
Company website: https://atomwise.com
LinkedIn: https://linkedin.com/company/atomwise
Ailynix
Developer of AI-blockchain drug design and discovery platform designed to focus on reinventing the approach to drug research and development.
Headquarter: Santa Clara, United States
Founded: 2019
Headcount: 4
Funding: Unknown
Company website: https://ailynix.com
LinkedIn: https://linkedin.com/company/ailynix
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